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Shining New Light on Alzheimer's Disease

$40,315
268%
Raised toward our $15,000 Goal
72 Donors
Project has ended
Project ended on May 03, at 11:59 PM CDT
Project Owners

Shining New Light on Alzheimer's Disease

Why We’re Excited

Our group in the department of chemistry has made a discovery that may lead to a new approach to treat Alzheimer's disease. Over the years we have been interested in finding better ways to make complex molecules that occur in nature – especially those that exhibit useful biological activity. A few years ago we received funding from the National Institutes of Health (NIH) to make collections of molecules related to some of these natural products for biological screening to identify new compounds that might lead to treatments for a variety of diseases.

We discovered one group of novel compounds that may have the power to go after neurodegenerative disorders, such as Alzheimer's disease. This is an exciting finding because no new drug for this disease has been approved since 2003; the only drugs available today merely transiently treat the symptoms of the disease. Bottom line: We are in desperate need of new and more effective therapeutic approaches that lead to cures of this debilitating disease.

Signs That We’re On To Something

Could our molecules that target a receptor (PGRMC1) not previously associated with Alzheimer’s disease offer a promising new therapeutic approach? We aimed to find out. First, we worked with researchers in the department of neuroscience here at UT to screen our compounds in a type of worm called C. elegans. Jim Sahn, on my team, and Luisa Scott in the Pierce-Shimomura lab in neuroscience conducted experiments and found some compounds did in fact reduce neurodegeneration in a novel worm model of Alzheimer's disease. This was an amazing discovery, but it was just the beginning.

Although these worms are useful for screening, we wanted to test our compound in an industry-accepted animal model for the disease. Accordingly, we used a mouse model for Alzheimer's disease and were even more thrilled when the mice treated with the compound had significantly better cognition than the untreated Alzheimer’s disease animals.

Where You Come In

We have something that works in both worms and mice. Will it work some day for people with this devastating disease? It will take a lot more work to find out, but if we’re right about this, we could be on the brink of a completely new way to treat Alzheimer’s disease with something that big pharmaceutical companies haven’t yet tried. If we’re successful, there’s a chance that what we do will lead to the development of more effective drugs that not only treat the symptoms of Alzheimer’s, but that also slow or even stop its progression.

Such a discovery represents the holy grail of Alzheimer’s research and would be game-changing.

Be A Part Of This Moment

We are now at a crossroad. We need additional funding so we can perform the necessary proof-of-principle studies so companies will invest in a valid new approach to tackling Alzheimer’s. Additional results will help us also make a compelling case to granting agencies like the NIH and various foundations that support research in this area.

We are asking for your help and support so that we can continue to develop this promising research into a novel therapy to help those suffering from Alzheimer’s disease. With your help, we believe we can make a difference.

This work started at UT – You can now help us continue research that might change the world by

Raising Your Horns Against Alzheimer's Disease.

 

 

Stephen Martin

Department of Chemistry , The University of Texas at Austin

Professor and M. June and J. Virgil Waggoner Regents Chair in Chemistry

http://www.cm.utexas.edu/stephen_martin

 

Levels
Choose a giving level

$25

Bevo's Helper

Your contribution is a first step toward discovering a new approach for treating Alzheimer's disease

$50

Texas Longhorn

Your contribution will provide a day's worth of laboratory supplies that are needed to make new compounds for biological testing.

$100

1st and Ten

Your contribution will support one day of housing for 50 animals that will be used to test how well our compounds enhance congnition.

$250

Red Zone

This level of support will enable us to breed 5000 worms that will be used to test our compounds for neuroprotective activity.

$500

Touchdown

Your contribution will help fund animal studies that show how well our compounds are able to reach the brain.

$1,000

Shut Out

Your contribution will pay for the supplies needed to make five new compounds for biological testing.

$5,000

Game Changer

Your contribution will provide substantial support for critical behavioral studies to test the cognition enhancing effects of a new preclinical candidate.

$10,000

Royal Supporter

Your contribution will fully fund animal safety studies for a preclinical candidate.

$25,000

Angel Sponsor

Your generous contribution will support a study to assess the cognition-enhancing effects of one promising preclinical drug candidate in an Alzheimer's disease animal model.

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